Table 3. Disease-Free Survival according to Body Mass Index Status and Tumor SUVbw in Stage I NSCLC Patients (n = 1,197).
Univariable HR (95% CI) | P | Multivariable HR* (95% CI) | P | |
---|---|---|---|---|
Normal weight | ||||
Low tumor SUVbw ≤ 5 (n = 304) | 1.00 (referent) | 1.00 (referent) | ||
High tumor SUVbw > 5 (n = 196) | 5.93 (3.50–10.01) | < 0.001 | 4.72 (2.77–8.06) | < 0.001 |
Overweight/obesity | ||||
Low tumor SUVbw ≤ 5 (n = 433) | 1.00 (referent) | 1.00 (referent) | ||
High tumor SUVbw > 5 (n = 264) | 3.61 (2.23–5.83) | < 0.001 | 2.61 (1.58–4.31) | < 0.001 |
P for interaction | 0.002 | < 0.001 |
*The multivariable Cox regression model stratified by body mass index status included lymphovascular invasion, visceral pleural invasion, and tumor SUV variables.
NSCLC, non-small cell lung cancer; SUVbw, maximum standardized uptake value normalized to body weight; HR, hazard ratio; CI, confidence interval