Table 1. Top 30 differentially expressed genes (up- and down- regulated) 1 hour after eFS.
| 1 hour post-eFS | ||||
|---|---|---|---|---|
| Upregulated genes | ||||
| Ensembl | genesymbol | Description | Fc | P-value BH-corrected |
| ENSMUSG00000028195 | Cyr61 | cysteine rich protein 61 | 8.04 | 0.0000 |
| ENSMUSG00000031558 | Slit2 | slit homolog 2 (Drosophila) | 5.68 | 0.0000 |
| ENSMUSG00000052684 | Jun | Jun oncogene | 3.13 | 0.0000 |
| ENSMUSG00000021250 | Fos | FBJ osteosarcoma oncogene | 3.04 | 0.0000 |
| ENSMUSG00000023034 | Nr4a1 | nuclear receptor subfamily 4, group A, member 1 | 2.99 | 0.0000 |
| ENSMUSG00000038418 | Egr1 | early growth response 1 | 2.62 | 0.0000 |
| ENSMUSG00000029657 | Hsph1 | heat shock 105kDa/110kDa protein 1 | 2.46 | 0.0000 |
| ENSMUSG00000004951 | Hspb1 | heat shock protein 1 | 2.40 | 0.0000 |
| ENSMUSG00000024190 | Dusp1 | dual specificity phosphatase 1 | 2.34 | 0.0000 |
| ENSMUSG00000005483 | Dnajb1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.25 | 0.0000 |
| ENSMUSG00000026628 | Atf3 | activating transcription factor 3 | 2.11 | 0.0000 |
| ENSMUSG00000019997 | Ctgf | connective tissue growth factor | 2.08 | 0.0000 |
| ENSMUSG00000022602 | Arc | activity regulated cytoskeletal-associated protein | 1.97 | 0.0000 |
| ENSMUSG00000006057 | Atp5g1 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9) | 1.90 | 0.0000 |
| ENSMUSG00000053877 | Srcap | Snf2-related CREBBP activator protein | 1.90 | 0.0000 |
| ENSMUSG00000028214 | Gem | GTP binding protein (gene overexpressed in skeletal muscle) | 1.89 | 0.0000 |
| ENSMUSG00000028907 | Utp11l | UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) | 1.86 | 0.0000 |
| ENSMUSG00000020205 | Phlda1 | pleckstrin homology-like domain, family A, member 1 | 1.75 | 0.0000 |
| ENSMUSG00000020818 | Mfsd11 | major facilitator superfamily domain containing 11 | 1.75 | 0.0000 |
| ENSMUSG00000021810 | Ecd | ecdysoneless homolog (Drosophila) | 1.68 | 0.0000 |
| ENSMUSG00000037266 | D4Wsu53e | DNA segment, Chr 4, Wayne State University 53, expressed | 1.65 | 0.0000 |
| ENSMUSG00000020423 | Btg2 | B cell translocation gene 2, anti-proliferative | 1.64 | 0.0000 |
| ENSMUSG00000030847 | Bag3 | BCL2-associated athanogene 3 | 1.63 | 0.0000 |
| ENSMUSG00000078698 | Mrgpra3 | MAS-related GPR, member A3 | 1.63 | 0.0000 |
| ENSMUSG00000021453 | Gadd45g | growth arrest and DNA-damage-inducible 45 gamma | 1.62 | 0.0000 |
| ENSMUSG00000031765 | Mt1 | metallothionein 1 | 1.61 | 0.0000 |
| ENSMUSG00000021367 | Edn1 | endothelin 1 | 1.59 | 0.0000 |
| ENSMUSG00000073676 | Hspe1 | heat shock protein 1 (chaperonin 10) | 1.56 | 0.0000 |
| ENSMUSG00000032531 | Amotl2 | angiomotin-like 2 | 1.55 | 0.0000 |
| ENSMUSG00000048222 | Mfap1b | microfibrillar-associated protein 1B | 1.54 | 0.0000 |
| Downregulated genes | ||||
| Ensembl | genesymbol | Description | Fc | P-value BH-corrected |
| ENSMUSG00000020863 | Luc7l3 | LUC7-like 3 (S. cerevisiae) | 0.62 | 0.0000 |
| ENSMUSG00000015090 | Ptgds | prostaglandin D2 synthase (brain) | 0.64 | 0.0000 |
| ENSMUSG00000041378 | Cldn5 | claudin 5 | 0.68 | 0.0000 |
| ENSMUSG00000071337 | Tia1 | cytotoxic granule-associated RNA binding protein 1 | 0.71 | 0.0000 |
| ENSMUSG00000030495 | Slc7a10 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 | 0.71 | 0.0000 |
| ENSMUSG00000029570 | Lfng | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.74 | 0.0000 |
| ENSMUSG00000046470 | Sox18 | SRY-box containing gene 18 | 0.74 | 0.0000 |
| ENSMUSG00000028645 | Slc2a1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.74 | 0.0000 |
| ENSMUSG00000000253 | Gmpr | guanosine monophosphate reductase | 0.77 | 0.0000 |
| ENSMUSG00000030218 | Mgp | matrix Gla protein | 0.78 | 0.0047 |
| ENSMUSG00000026822 | Lcn2 | lipocalin 2 | 0.78 | 0.0009 |
| ENSMUSG00000030711 | Sult1a1 | sulfotransferase family 1A, phenol-preferring, member 1 | 0.79 | 0.0000 |
| ENSMUSG00000040055 | Gjb6 | gap junction protein, beta 6 | 0.80 | 0.0000 |
| ENSMUSG00000048001 | Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.81 | 0.0000 |
| ENSMUSG00000046546 | Fam43a | family with sequence similarity 43, member A | 0.81 | 0.0000 |
| ENSMUSG00000032422 | Snx14 | sorting nexin 14 | 0.81 | 0.0000 |
| ENSMUSG00000029231 | Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.81 | 0.0000 |
| ENSMUSG00000050505 | Pcdh20 | protocadherin 20 | 0.81 | 0.0000 |
| ENSMUSG00000022508 | Bcl6 | B cell leukemia/lymphoma 6 | 0.82 | 0.0000 |
| ENSMUSG00000030707 | Coro1a | coronin, actin binding protein 1A | 0.82 | 0.0000 |
| ENSMUSG00000041073 | Nacad | NAC alpha domain containing | 0.82 | 0.0000 |
| ENSMUSG00000016921 | Srsf6 | serine/arginine-rich splicing factor 6 | 0.82 | 0.0000 |
| ENSMUSG00000038175 | Mylip | myosin regulatory light chain interacting protein | 0.82 | 0.0000 |
| ENSMUSG00000017760 | Ctsa | cathepsin A | 0.82 | 0.0000 |
| ENSMUSG00000001240 | Ramp2 | receptor (calcitonin) activity modifying protein 2 | 0.82 | 0.0000 |
| ENSMUSG00000043131 | Mob1a | MOB kinase activator 1A | 0.82 | 0.0000 |
| ENSMUSG00000070167 | SNORA57 | Small nucleolar RNA SNORA57 | 0.83 | 0.0000 |
| ENSMUSG00000075602 | Ly6a | lymphocyte antigen 6 complex, locus A | 0.83 | 0.0000 |
| ENSMUSG00000028655 | Mfsd2a | major facilitator superfamily domain containing 2A | 0.83 | 0.0000 |
| ENSMUSG00000050295 | Foxc1 | forkhead box C1 | 0.84 | 0.0000 |
Fc: Fold change represents expression values of HT animals divided by expression values of NT animals. P-value BH-corrected: Benjamini and Hochberg (BH) error corrected p-values.