Table 1. Hemodynamic variables.

	baseline	drug perfusion	ischemia	reperfusion
			30	30	60
Heart Rate (bpm)
con	326 ± 29	330 ± 43		293 ± 36	275 ± 24
sil	305 ± 28	336 ± 20		330 ± 39	278 ± 26
pax+sil	308 ± 58	308 ± 57		264 ± 50	277 ± 41
pax	338 ± 50	334 ± 53		296 ± 50	275 ± 37
RPP (mmHg * bpm)
con	42704 ± 6340	42704 ± 6340		7940 ± 4844*	9544 ± 3368*
sil	43200 ± 9234	46046 ± 6831		8662 ± 5223*	9972 ± 2840*
pax+sil	45168 ± 9736	43034 ± 8034		7817 ± 4875*	10135 ± 2852*
pax	44487 ± 6362	40855 ± 7904		6873 ± 2347*	8018 ± 2185*
LVEDP (mmHg)
con	7 ± 3	8 ± 3	39 ± 9*	85 ± 15*	78 ± 13*
sil	8 ± 1	10 ± 1	33 ± 6*	87 ± 13*	80 ± 11*
pax+sil	9 ± 4	11 ± 3	36 ± 4*	84 ± 8*	77 ± 10*
pax	10 ± 5	14 ± 6	40 ± 12*	89 ± 15*	82 ± 15*
Coronary flow (ml * min -1 /g dry heart weight)
con	105 ± 15	113 ± 17		66 ± 15*	57 ± 12*
sil	107 ± 10	117 ± 9		60 ± 15*	55 ± 17*
pax+sil	114 ± 16	114 ± 19		51 ± 22*	51 ± 5*
pax	112 ± 13	103 ± 13		61 ± 11*	53 ± 8*

Data are mean±SD. con = control; sil = sildenafil; pax = paxilline. RPP = rate pressure product; LVEDP = left ventricular end-diastolic pressure.

*P<0.05 versus baseline.