Figure 1. Serum IgG antibody responses to the MenB-4C vaccine.

Each symbol represents a titer of an individual animal as measured by ELISA. Pre-dose 1 titers were negative (<1:100) as were post-dose 2 and post-dose 3 titers of six negative control unvaccinated animals (data not shown). Left. Macaques with FH^high phenotype. Right. Macaques with FH^low phenotype. A. Anti-FHbp; B. Anti-NOMV; C. Anti-NadA; and D. Anti-NHba. Compared to post-dose 2, the respective titers after dose 3 did not increase and in some groups the titers decreased to specific antigens. For example, after dose 3 the anti-NadA titers were lower than after dose 2 in both groups of macaques. After dose 3, the anti-NHba titers were lower in the FH^high group (left), and the anti-FHbp titers were lower in the FH^low group. *, p≤0.05; **, p≤0.01 by paired t-test.