Table 3.
Multivariate association results for time to renal allograft failure, based on APOL1 genotype (recessive model), with data set reduced to common sample size
| Further-Adjusted Model (Full Model + 4 additional covariates)* |
Full Model | |||||
|---|---|---|---|---|---|---|
| Variable | Hazard Ratio | 95% Confidence Interval |
P-value | Hazard Ratio |
95% Confidence Interval |
P-value |
| APOL1 (recessive model) | 1.65 | (1.08,2.52) | 0.02 | 1.65 | (1.14,2.38) | 0.007 |
| Increasing donor age | 1.12 | (0.93,1.34) | 0.22 | 1.17 | (0.99,1.38) | 0.07 |
| Maximum panel reactive antibodies | 1.00 | (1.00,1.01) | 0.20 | 1.00 | (1.00,1.01) | 0.47 |
| Increasing recipient age | 0.78 | (0.60,1.02) | 0.07 | 0.71 | (0.57,0.88) | 0.002 |
| Number of HLA mismatches | 0.98 | (0.87,1.10) | 0.74 | 0.98 | (0.88,1.09) | 0.66 |
| Cold ischemia time | 1.02 | (1.00,1.04) | 0.01 | 1.01 | (0.99,1.02) | 0.26 |
| Expanded-criteria donor (Yes) | 1.66 | (1.03,2.67) | 0.04 | 1.62 | (1.04,2.52) | 0.03 |
| Recipient gender (Female) | 1.14 | (0.81,1.60) | 0.46 | 0.99 | (0.72,1.36) | 0.96 |
| Recipient diabetic kidney disease (Yes) | 1.45 | (0.94,2.24) | 0.09 | - | - | - |
| Recipient body mass index | 1.01 | (0.98,1.04) | 0.50 | - | - | - |
| Acute rejection (Yes) | 5.39 | (3.82,7.59) | 5.7×10−22 | - | - | - |
| Delayed allograft function (Yes) | 2.03 | (1.44,2.86) | 5.4×−10−5 | - | - | - |
| Induction immunosuppression (Yes) | 0.78 | (0.50,1.22) | 0.28 | - | - | - |
| Source/Recipient ethnicity (reference WFU/Other) | Overall interaction p-value 0.02 | Overall interaction p-value 0.04 | ||||
| WFU/AA | 1.00 | (0.61,1.64) | 1.00 | 1.40 | (0.89,2.20) | 0.14 |
| DeKAF Genomics/AA | 1.11 | (0.71,1.73) | 0.65 | 1.60 | (1.25,2.04) | 0.0002 |
| DeKAF Genomics/Other | 0.32 | (0.14,0.72) | 0.01 | 0.37 | (0.17,0.80) | 0.01 |
| Emory/AA | 0.70 | (0.46,1.08) | 0.11 | 1.04 | (0.83,1.30) | 0.74 |
| Emory/Other | 0.64 | (0.29,1.39) | 0.26 | 0.73 | (0.36,1.47) | 0.38 |
| UAB/AA | 0.91 | (0.41,2.03) | 0.83 | 0.77 | (0.48,1.25) | 0.29 |
| UAB/Other | 0.24 | (0.06,1.01) | 0.05 | 0.24 | (0.06,1.00) | 0.05 |
*
Additional covariates: recipient diabetic kidney disease, body mass index, dialysis vintage and induction immunosuppression;
AA – African American; Other – non-African Americans