Table 4.
Competing risk model for association between time to allograft failure and death in the full sample
| Event | Label | Hazard Ratio | 95% CI | P-value |
|---|---|---|---|---|
| Allograft failure | APOL1 (recessive model) | 1.61 | (1.05,2.47) | 0.028 |
| Panel reactive antibodies | 1.00 | (1.00,1.01) | 0.24 | |
| Increasing donor age | 1.13 | (0.96,1.32) | 0.14 | |
| Increasing recipient age | 0.88 | (0.75,1.04) | 0.13 | |
| Number of HLA mismatches | 0.97 | (0.88,1.07) | 0.53 | |
| Cold ischemia time | 1.01 | (1.00,1.03) | 0.09 | |
| Expanded-criteria donor (Yes) | 1.39 | (0.84,2.30) | 0.21 | |
| Recipient gender (Female) | 1.03 | (0.74,1.43) | 0.88 | |
| Acute rejection (Yes) | 4.27 | (3.00,6.09) | <0.0001 | |
| Delayed allograft function (Yes) | 1.92 | (1.37,2.68) | 0.0002 | |
| Induction immunosuppression (Yes) | 0.68 | (0.46,1.00) | 0.049 | |
| Recipient diabetic kidney disease (Yes) | 1.36 | (0.91,2.03) | 0.13 | |
| Recipient WFU/AA* | 1.10 | (0.71,1.71) | 0.68 | |
| Recipient Emory University/Other* | 0.63 | (0.31,1.31) | 0.22 | |
| Recipient UAB/Other* | 0.22 | (0.05,0.97) | 0.046 | |
| Recipient DeKAF Genomics/Other* | 2.65 | (1.08,6.51) | 0.034 | |
| Recipient Emory University/AA* | 0.51 | (0.30,0.88) | 0.016 | |
| Recipient UAB/AA* | 0.97 | (0.60,1.56) | 0.88 | |
| Recipient DeKAF Genomics/AA* | 1.07 | (0.01,107.23) | 0.98 | |
| Death with functioning allograft | APOL1 (recessive model) | 1.07 | (0.61,1.89) | 0.80 |
| Panel reactive antibodies | 1.00 | (0.99,1.00) | 0.38 | |
| Increasing donor age | 1.22 | (0.97,1.53) | 0.09 | |
| Increasing recipient age | 1.15 | (0.93,1.41) | 0.21 | |
| Number of HLA mismatches | 1.06 | (0.88,1.27) | 0.55 | |
| Cold ischemia time | 0.99 | (0.97,1.01) | 0.30 | |
| Expanded-criteria donor (Yes) | 0.73 | (0.37,1.46) | 0.37 | |
| Recipient gender (Female) | 0.96 | (0.61,1.50) | 0.85 | |
| Acute rejection (Yes) | 0.58 | (0.32,1.07) | 0.08 | |
| Delayed allograft function (Yes) | 0.94 | (0.57,1.55) | 0.81 | |
| Induction immunosuppression (Yes) | 1.75 | (0.86,3.58) | 0.12 | |
| Recipient diabetic kidney disease (Yes) | 1.21 | (0.78,1.87) | 0.41 | |
| Recipient WFU/AA* | 0.68 | (0.34,1.36) | 0.27 | |
| Recipient Emory University/Other* | 1.61 | (0.79,3.30) | 0.19 | |
| Recipient UAB/Other* | 0.42 | (0.12,1.42) | 0.16 | |
| Recipient DeKAF Genomics/Other* | 1.09 | (0.35,3.38) | 0.88 | |
| Recipient Emory University/AA* | 0.55 | (0.37,0.82) | 3.3×10−3 | |
| Recipient UAB/AA* | 1.94 | (1.35,2.76) | 2.9×10−4 | |
| Recipient DeKAF Genomics/AA* | 0.90 | (0.15,5.57) | 0.91 |
*
Reference group is WFU/Other (Wake Forest University non-African American Recipients)