Table 1.
Top ranked biological processes enriched by genes co-regulated in zebrafish larvae exposed from 4 dpf to 6 dpf to 2 μM T0 or 1 μM GW.
| Enriched biological process |
Zf Gene Symbol | p-value | GO ID |
|---|---|---|---|
| Lipid metabolic process |
apoea,abca1a,abcg1, apoa4, ldlrb, abcg8, srebf1, abcg5, scd,
acaca, lipeb, dgat2, nr1h3, pltp, insig1, acsl3b, acsl4a, lipg, fads2, lipin2, ch25hl1.1, echs1, sc5dl, sult2st1, soat2, lipi, acsbg2 |
2.77E-27 | 6629 |
| Lipid biosynthetic process |
hmgcra, srebf1, scd, acaca, fasn, dgat2, elovl2, cyp51, mvd, lss, hsd17b7,
fads2, ch25hl1.1, msmo1, ebp, sc5dl |
2.79E-20 | 8610 |
| Cholesterol homeostasis |
apoea,abca1a,abcg1, ldlrb, apoa4, abcg8, abcg5, g6pca.1, nr1h3, lipg,
mylipa, soat2 |
5.51E-18 | 42632 |
|
Cholesterol metabolic
process |
apoea, abca1a, abcg1, ldlrb, apoa4, srebf1, lipeb, insig1, sqlea,
ch25hl1.1, ebp, soat2 |
2.10E-16 | 8203 |
|
Cholesterol biosynthetic
process |
hmgcra, insig1, cyp51, mvd, sqlea, lss, hsd17b7, msmo1, ebp, scd5l | 4.33E-16 | 6695 |
| Sterol biosynthetic process | hmgcra, insig1, cyp51, mvd, sqlea, ch25hl1.1, msmo1, ebp, scd5l | 1.28E-15 | 16126 |
| Response to nutrient |
bcl2, hmgcra, abca1a, abcg8, abcg5, aglb, acsl3b, acsl4a, mgp,
a2ml, lipg, slc6a19a, soat2 |
3.68E-15 | 7584 |
| Cholesterol efflux | apoea, abca1a, abcg1, apoa4, abcg8, abcg5, abcg4, soat2 | 5.79E-14 | 33344 |
|
Steroid biosynthetic
process |
hmgcra, prlra, cyp51, mvd, lss, hsd17b7, ch25hl1.1, msmo1, ebp, scd5l | 8.07E-13 | 6694 |
| Metabolic process |
abca1a, abcg1, prkg1a, atp1a1a.2, ca4c, aanat2, abcg5, scd, acaca,
g6pca.1, lipeb, fasn, insig1, ids, cox6a2, acsl3b, acsl4a, zgc:101000, hsd17b7, fads2, sqlea, mylipa, abcd3a, cdc42bpa, ch25hl1.1, msmo1, ebp, atp6v1e1b, echs1, pank1a, grhprb, dera, ggctb, acsbg2, agxt2l1 |
1.02E-12 | 8152 |
|
Fatty acid biosynthetic
process |
scd, acaca, fasn, nr1h3,elovl2, acsl3b, fads2,ch25hl1.1, msmo1,scd5l | 1.30E-12 | 37 |
Bold font indicates genes significantly upregulated by both LXR ligands, while downregulated genes are in regular font. Underlined genes were upregulated by T0 and downregulated by GW.