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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Pharmacol Res. 2015 Sep 8;102:22–32. doi: 10.1016/j.phrs.2015.09.006

Fig. 7.

Fig. 7

Desensitization of CB1Rs in mouse hypothalamus (top), but not cortex (bottom), when stimulated with a receptor-saturating concentration (10 µM) of JWH-018. Prior to tissue harvesting, mice (n = 4 per group) were treated with vehicle (black), 30 mg/kg Δ9-THC (white) or 10 mg/kg JWH-073 (striped), once per day for 4 days. Values designated with different letters above the error bars are significantly different (P<0.05, one-way ANOVA followed by a Tukey’s post-hoc test, mean ± SEM).