Table 2.

Circulation half-lives of liposomes incorporating polymers for a single dose vs. the second dose (“PMOX+”=PMOX with cationic linker to lipid). (n = 3 per group for animals receiving a single dose, n = 4 per group for animals receiving 2 doses). Only the PEG and PMOX modified liposomes had significantly different circulation times compared at the first and second doses.

	Dose	Half-life (h)	AUC
PEG	1	33.6 ± 1.3	2586 ± 12
	2	1.66 ± 0.8**	89 ± 18***
PMOX	1	30.5 ± 2.5	2605 ± 21
	2	1.9 ± 0.5**	89 ± 5***
PVP	1	20.7 ± 1.3	1524 ± 56
	2	19.7 ± 2.6	1512 ± 56
PDMA	1	16.0 ± 1.2	1346 ± 54
	2	15.0 ± 2.8	1387 ± 47
HPMA	1	16.0 ± 1.2	1138 ± 42
	2	15.5 ± 2.8	953 ± 44*
PAcM	1	16.4 ± 1.8	918 ± 36
	2	16.3 ± 2.7	832 ± 16
No Polymer	1	12.0 ± 0.2	717 ± 40
	2	12.3 ± 1.8	712 ± 37
PMOX (+)	1	30.5 ± 2.5	2570 ± 25
	2	2.1 ± 0.5	80 ± 6***

^*, p < 0.05,

^**, p < 0.005,

^***, p < 0.001.