Table 5.
Comparison of symptom severity at study enrollment among individuals with H3N2 infection
| Moderate/Severe (vs. None/Mild) | Severe only (vs. None/Mild/Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Bivariate analysis | Multivariate analysis | Bivariate analysis | Multivariate analysis | |||||||
| Unvaccinated n=14 | Vaccinated n=52 | P-value | OR2 | 95% CI | Unvaccinated n=14 | Vaccinated n=52 | P-value | OR2 | 95% CI | |
| Chills | 9 (64.3) | 29 (55.8) | 0.567 | 5 (35.7) | 7 (13.5) | 0.055* | ||||
| Cough | 13 (92.9) | 39 (75.0) | 0.2691 | 6 (42.9) | 16 (30.8) | 0.394 | ||||
| Rhinorrhea | 12 (85.7) | 30 (57.7) | 0.0661 | 5 (35.7) | 9 (17.3) | 0.135 | ||||
| Earache | 5 (35.7) | 18 (34.6) | 0.939 | 1 (7.1) | 7 (13.5) | 1.0001 | ||||
| Sneezing | 7 (50.0) | 11 (21.2) | 0.032** | 0.393 | (0.08, 1.83) | 1 (7.1) | 4 (7.7) | 1.0001 | ||
| Sore throat | 10 (71.4) | 24 (46.2) | 0.093 | 4 (28.6) | 7 (13.5) | 0.2271 | ||||
| Eye issues | 4 (28.6) | 12 (23.1) | 0.7301 | 1 (7.1) | 4 (7.7) | 1.0001 | ||||
| Nausea | 3 (21.4) | 6 (11.5) | 0.3871 | 1 (7.1) | 2 (3.9) | 0.5171 | ||||
| Vomiting | 0 (0) | 1 (1.9) | 1.0001 | 0 (0) | 1 (1.9) | 1.0001 | ||||
| Diarrhea | 0 (0) | 1 (1.9) | 1.0001 | 0 (0) | 1 (1.9) | 1.0001 | ||||
| Hoarseness | 4 (28.6) | 16 (30.8) | 1.0001 | 2 (14.3) | 8 (15.4) | 1.0001 | ||||
| Joint pain | 10 (71.4) | 29 (55.8) | 0.290 | 6 (42.9) | 13 (25.0) | 0.190 | ||||
| Dyspnea | 6 (42.9) | 10 (19.2) | 0.067 | 1 (7.1) | 4 (7.7) | 1.0001 | ||||
| Myalgia | 10 (71.4) | 37 (71.2) | 0.984 | 5 (35.7) | 15 (28.9) | 0.620 | ||||
| Headache | 11 (78.6) | 31 (59.6) | 0.2271 | 4 (28.6) | 16 (30.8) | 1.0001 | ||||
| Fatigue | 13 (92.9) | 34 (65.4) | 0.052 | 9 (64.3) | 16 (30.8) | 0.022** | 0.44 | (0.10, 1.84) | ||
| Dizziness | 4 (28.6) | 10 (19.2) | 0.4731 | 1 (7.1) | 4 (7.7) | 1.0001 | ||||
| Appetite loss | 12 (85.7) | 25 (48.1) | 0.0151** | 0.27 | (0.04, 1.72) | 8 (57.1) | 11 (21.2) | 0.008** | 0.27* | (0.06, 1.21) |
| Abdominal pain | 3 (21.4) | 7 (13.5) | 0.4311 | 0 (0) | 1 (1.9) | 1.0001 | ||||
| Chest pain | 7 (50.0) | 7 (13.5) | 0.003** | 0.173** | (0.03, 0.89) | 3 (21.4) | 3 (5.8) | 0.1041 | ||
1
P-value of exact test.
2
Odds ratios from multivariate logistic regression, adjusting for sex, influenza season and use of antiviral drugs. Multivariate analysis is only performed on symptoms with p-value <0.05 in the bivariate analysis.
95% CI: 95% confidence interval
**
p<0.05.