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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Neuroendocrinology. 2015 Jun 18;103(3-4):230–239. doi: 10.1159/000435884

Table 4.

In silico prediction of the variants derived from the Ensembl database.

SIFT Polyphen-2
Tolerated Deleterious Benign Damaging
GnRHR 22 30 25 31
KISS1R 23 17 12 18
PROKR2 48 50 53 51
TACR3 78 54 56 70
Total 171 151 146 170
Percentage * 53.1 46.9 46.2 53.8
*

Percentage of total receptors predicted by SIFT or Polyphen-2