Skip to main content
. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: J Control Release. 2015 Jun 18;213:36–44. doi: 10.1016/j.jconrel.2015.06.021

Figure 4. Biodistribution and Serum Clearance of Native SOD1 and Cl-nanozyme in healthy mice.

Figure 4

A. C57BL/6 mice received IV bolus injection of either 125I-labeled native SOD1 (n=7), or cl-nanozyme (n=8). One hour later organs were harvested and radioactivity was measured. Results represent mean % of injected dose per gram of tissue (ID%/g) with error bars representing ±SEM. Statistical significance was determined by Student’s t-test (indicated as follows: n.s., not significant; *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001); B. Serum clearance profiles of native SOD1 and cl-nanozyme were plotted and analyzed by linear regression fitting. The serum half-life was 33.8 min (R2=8966, P<0.0005; n=1–2 mice/time point) for cl-nanozyme, and 10.3 min (R2=8156, P<0.05; n=1–2 mice/time point) for native SOD1.