In vivo evaluation of (A) prolonged viral gene expression by bioluminescence generated by luciferase and (B) tumor size reduction by SELP815K, SELP815K-RS1, SELP815K-RS2, and SELP815K-RS5 matrix mediated local delivery. 815K:SELP815K, RS1:SELP815K-RS1, RS2:SELP815K-RS2, RS5:SELP815K-RS5. ***- p≤0.001 between control (PBS) group and treatment groups by one way ANOVA with Bartlett post-test. (A)Data displayed on normal (main graph) and log scale (inset). Error bars represent standard error of mean.