TABLE 4.

Somers’ D associations and risk allele frequency for 2 SNPs and postflight ophthalmic outcomes

	MTRR 66 A→G		SHMT1 1420 C→T
Ophthalmic outcome	Somers’ D	G allele frequency (case/noncase)	Somers’ D	C allele frequency (case/noncase)
Optic disc edema	—		−0.36**	0.94/0.75
Choroidal folds	0.37*	0.67/0.43	—
Cotton wool spot	0.53**	0.80/0.46	—

There were no significant associations between MTHFR 677 C→T, MTHFR 1298 A→C, or CBS 844ins68 and disc edema, choroidal folds, globe flattening, cotton wool spots, or change in diopters. Forty-nine subjects were evaluated for optic disc edema and choroidal folds and 39 for cotton wool spots.

^*P < 0.05 (unadjusted);

^**P < 0.01 (unadjusted).