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Characterization of AT2CC−/− mice. A) Whole lungs were isolated from WT and AT2CC−/− mice and COX-2 expression was assessed by real-time RT-PCR. The ratio relative to WT is shown (n = 5). ATII cells were isolated from WT and AT2CC−/− mice, and levels of SPC mRNA (B), COX-2 mRNA (C), COX-2 protein (D), PTGDS mRNA (E), and PTGES mRNA (F) were quantified (n = 8–10). *P < 0.05 vs. WT.
