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. 2015 Sep 22;30(1):160–173. doi: 10.1096/fj.14-268458

Figure 4.

Figure 4.

Effect of LPS on airway responsiveness and BALF cells in WT and AT2CC−/− mice. WT and AT2CC−/− mice were treated with saline or LPS (50 µg via oropharyngeal aspiration) for 4 h. A) Body temperatures were recorded hourly throughout the 4-h period. Mice were then placed on the Flexivent to assess airway responsiveness to increasing doses of aerosolized methacholine (3.125, 6.25, 12.5, and 25 mg/ml). Provocative concentrations for R (B), Rn (C), G (D), and E (E), were calculated by extrapolation of the respective dose–response curves. F) BALF was collected from the mice and the counts of total cells, neutrophils, and macrophages were determined (n = 10–12). *P < 0.05 vs. respective saline; #P < 0.05 vs. WT saline; †P < 0.05 vs. WT LPS.