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. 2015 Sep 22;30(1):160–173. doi: 10.1096/fj.14-268458

Figure 7.

Figure 7.

Bleomycin-induced lung dysfunction and fibrosis in WT and AT2CC−/− mice. WT and AT2CC−/− mice were treated with saline or bleomycin (1 mg/kg body weight) via oropharyngeal aspiration and studied 21 d later. COX-1 (A) and COX-2 (B) mRNA levels in whole lungs were determined by real-time RT-PCR. C) Body weights of mice 1 wk after bleomycin/saline administration. D) Lung function measured as Cst by Flexivent. E) Caudal lung lobes were lysed, and collagen content was measured by colorimetric assay. F) BALF was collected, and the counts of total cells, macrophages, and lymphocytes were assessed (n = 8–10). *P < 0.05 vs. saline of same genotype; #P < 0.05 vs. WT saline.