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. 2015 Aug 27;30(1):102–110. doi: 10.1096/fj.15-275891

Figure 3.

Figure 3.

TRPC1 deletion induces SPHK1 expression and S1P generation. SPHK activity (A) or S1P generation (B) after stimulation with or without thrombin of WT and TRPC1-null ECs. C) SPHK mRNA expression in Trpc1−/− or WT EC. *Values different from WT ECs (P < 0.05). D) SPHK protein expression using specific antibodies. E) Changes in TER in ECs upon pertussis toxin addition and after stimulation with thrombin. *Values different from vehicle; **values different from vehicle-treated cells after thrombin challenge; P < 0.05.