Table 2.

Association between pathological findings and molecular profile

No.	Sex	Diagnostic procedure	Smoking index	EGFR mutation	KRAS mutation	ALK IHC	Pathological features
							Epithelial component	Sarcomatoid component
1	M	Surgery	2100	Wild	Mutated	Negative	Adeno	Giant cell > Spindle cell
2	F	Surgery	0	Exon 19 del	Wild	Negative	Adenosquamous	Spindle cell > Giant cell
3	M	Surgery	1200	Wild	Wild	Negative	Adeno	Spindle cell > Giant cell
4	F	Surgery	0	Wild	Wild	Negative	Adeno	Spindle cell > Giant cell
5	M	Surgery	400	Wild	Wild	Negative	Adeno	Spindle cell > Giant cell
6	M	Surgery	1800	Wild	Wild	Negative	Squamous	Spindle cell > Giant cell
7	F	Surgery	600	Wild	Wild	Negative	Adeno	Spindle cell > Giant cell
8	F	Surgery	345	Wild	Mutated	Negative	Large	Giant cell > Spindle cell
9	M	Autopsy	495	NA	NA	NA	NOS	Giant cell > Spindle cell
10	M	Biopsy	2480	Wild	Wild	Negative	NOS	Giant cell
11	M	Autopsy	480	Wild	Wild	Negative	Adeno	Giant cell
12	M	Biopsy	1600	Wild	Mutated	Negative	Squamous	Spindle cell > Giant cell
13	M	Surgery	660	Wild	Wild	Negative	Large	Giant cell > Spindle cell
14	M	Autopsy	1160	Wild	Wild	Negative	Adeno	Giant cell > Spindle cell
15	F	Surgery	0	Exon 21 L858R	Wild	Negative	Large	Spindle cell > Giant cell
16	F	Biopsy	0	NA	NA	NA	Large	Spindle cell > Giant cell

IHC immunohistochemistry, NOS not otherwise specified, Adeno adenocarcinoma, Squamous squamous cell carcinoma, Large large cell carcinoma, Adenosquamous adenosquamous carcinoma