Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Diagram of the activation of NRF2. Calorie restriction and a number of phytochemicals are able to induce the release of NRF2 from Keap1, allowing it to enter into the nucleus. Once in the nucleus, NRF2 binds to ARE sequences in the promoter of antioxidant and detoxifying enzymes, inducing their expression. Increased levels of these NRF2 downstream targets prevent age-related increases in cancer and ameliorates other age-related diseases, leading to an improved quality of life.
