Table 2.
NRF2 downstream targets involved in cancer protection
| Gene | Role in cancer prevention/cancer growth |
References |
|---|---|---|
| GPX2 | Inflammatory response | Banning et al., 2008 |
| PRDX1 | Antioxidant | Cao et al., 2009 |
| PRDX61 | Antioxidant | Chang et al., 2007 |
| NQO1 | Antioxidant | Nolan et al., 2010 |
| CBR1 | Antioxidant | La1 et al., 2008 |
| CBR3 | Antioxidant | La1 et al., 2008 |
| CYP2B9 | Drug metabolism | Muguruma et al., 2006 |
| FMO2 | Drug metabolism | Fialka et al., 2008 |
| FMO3 | Drug metabolism | Bae et al., 2006 |
| GSTA1 | ROS protection | Nguyen et al., 2010 |
| GSTM1 | ROS protection | Nguyen et al., 2010 |
| GSTP1 | ROS protection | Nguyen et al., 2010 |
| GSTT1 | ROS protection | Nguyen et al., 2010 |
| MGST3 | ROS protection | Efferth and Volm, 2005 |
| ALDH3A1 | Metabolism | Patel et al., 2008 |
| GADD45G | DNA repair | Baguley, 2010 |
| HSP40 | Stress resistance | Mitra et al., 2009 |
| HSP70 | Stress resistance | Wang et al., 2010 |
Abbreviation: NRF2, NF-E2-related factor; ROS, reactive oxygen species.