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. 2015 Oct 9;7(10):2929–2940. doi: 10.1093/gbe/evv191

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© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2.— — Functional effects caused by nonsynonymous SNPs as a function of DAF. (A) Amino acid chemical distance caused by nonsynonymous SNPs as a function of DAF; (B) Change in amino acid hydrophobicity index (|ΔH|) as a function of DAF; (C) BLOSUM62 scores as a function of DAF; (D) SIFT scores as a function of DAF; (E) Comparison of the functional effect caused by nonsynonymous SNPs between the genes undergoing stronger and weaker purifying selection. The median of ω (calculated using mouse orthologs) is used as the cutoff. Each point represents the mean of the corresponding category. Error bars indicate the standard error of the mean.