Table 1.
Synthetic 42F3 Peptide Signaling and Binding Properties.
| Peptide | Sequence | EC50 (μM) | Emax (IL-2 pg/ml) | KD (μM)* | koff (s−1) | kon (M−1s−1) |
|---|---|---|---|---|---|---|
| QL9 | QLSPFPFDL | 0.0447 | 399 | 40 | >5.00E-01 | N.D. |
| p4B10 | QLSDVPMDL | 0.000164 | 3297 | 10 | >5.00E-01 | N.D. |
| p5E8 | FLSPFWFDI | 1.38 | 3349 | 48 | >5.00E-01 | N.D. |
| pCPA12 | VPYMAEFGM | 5.95 | 1149 | 2 | 5.79E-02 | 3.14E+04 |
| pCPC5 | SPAPRPLDL | 0.416 | 363 | 1 | 1.97E-01 | 2.70E+04 |
| pCPE3 | MPAGRPWDL | >100 | N.D. | 0.7 | 1.66E-01 | 5.86E+04 |
| pCPB7 | WPAEGGFQL | 0.00286 | 2844 | 0.1 | 5.79E-02 | 4.95E+05 |
| pCPB9 | SPAEAGFFL | 0.07 | 3144 | 0.1 | 6.68E-02 | 2.40E+05 |
| p3A1 | SPLDSLWWI | inactive | inactive | 4 | 7.52E-01 | 2.01E+05 |
*
Values obtained from steady-state experiment.
N.D. - Not determined