. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Trends Pharmacol Sci. 2015 Oct 17;36(12):858–877. doi: 10.1016/j.tips.2015.08.013

Table 1.

Expression, subcellular localization, and physiological function of Plks

	Expression	Localization	Function
Plk1	Actively dividing cells	Centrosomes, kinetochores, midbody	G2/M transition, mitotic progression, cytokinesis
Plk2	Less-dividing cells	Centrosomes	Stress-response, centriole duplication
Plk3	Less-dividing cells	Centrosomes, midbody, nucleolus	Genotoxic, hypoxic & oxidative stress response, p53 activation
Plk5	Non-dividing cells	Cytoplasm	Neuritic process
Plk4	Actively dividing cells	Centrosomes	Centriole biogenesis