Table 2.

Effects of KOR antagonist (JDTic) and CRF-R1 antagonist (Antalarmin) pretreatment on 5CSRTT metrics

Metric	Corre ct (%)	Omissi ons (%)	Accura cy	Head Entri es	Rewa rd Laten cy	Laten cy to Corre ct	Time to Compl ete Task	Premat ure Respon ses	Post- Corre ct	Post- Erro r
PACAP Alone (0.5 μg)
PACAP	26.48 ±13.23	65.19 ±15.69	54.74 ±14.48	93.83 ±39.89	1.56 ±0.34	1.17 ±0.35	1249 ±60.4	3.83 ±1.49	33.07 ±15.13	27.03 ±13.09
Antalarmin (ANT) Pretreatment
CMC +VEH	77.59 ±2.30	4.81 ±1.1	81.62 ±2.81	160.5 ±8.99	1.89 ±0.41	0.81 ±0.06	1042 ±37.53	11.0 ±3.49	75.41 ±3.32	72.71 ±5.56
ANT+VEH	73.89 ±1.9	4.07 ±1.02	77.03 ±1.81	152.0 ±13.97	1.48 ±0.11	081 ±0.06	1055 ±31.85	15.0 ±3.69	72.67 ±3.51	75.12 ±5.21
ANT+PACAP	51.67 ±14.31	34.07 ±17.04	62.43 ±13.29	118.3 ±25.47	1.89 ±0.28	1.25 ±0.20	1154 ±72.69	7.33 ±2.77	56.85 ±13.92	45.09 ±15.4
Statistics	F(2,10) = 2.75, P=0.11 n.s.	F(2,10)=3.13, P=0.09 n.s.	F(2,10)= 158, P=0.25 n.s.	F(2,10) = 1.77, P=0.22 n.s.	F(2,10) = 1.88, P=0.21 n.s.	F(2,10) = 3.39, P=0.08 n.s.	F(2,10)= 1.22, P=0.34 n.s.	F(2,10)= 1.07, P=0.38 n.s.	F(2,20)=0.28 P=0.76, n.s.
JDTic Pretreatment
SAL+VEH	72.78±4.12	5.74 ±1.14	77.50 ±4.12	145.8 ±13.91	1.56 ±0.15	0.87 ±0.087	1032 ±14.21	10.33 ±2.39	66.55 ±4.5	76.95 ±8.45
JDTic+VEH	70.56 ±3.86	6.48 ±2.14	77.07 ±2.84	157.0 ±17.35	1.47 ±0.104	0.94 ±0.08	1034 ±17.98	10.17 ±2.14	66.23 ±5.93	70.77 ±2.99
JDTic+PACAP	30.09 ±12.35 **	55.0 ±18.06*	53.34 ±13.64	61.17 ±23.84 **	1.54 ±0.156	0.93 ±0.22	1221 ±65.0*	7.33 ±2.65	53.63 ±11.69	43.55 ±17.23
Statistics	F(2,10) = 10.93, P<0.01	F(2,10)= 8.31, P<0.01	F(2,10)= 0.11, P=0.151 n.s.	F(2,10) = 13.25, P<0.01	F(2,10) = 0.88, P=0.45 n.s.	F(2,10) = 0.14, P=0.87 n.s.	F(2,10)= 8.0, P<0.01	F(2,10)= 1.16, P=0.35 n.s.	F(2,20)=0.53 P=0.59, n.s.

^*P<0.05,

^**P<0.01 compared to JDTic+VEH group. Pretreatment groups represented as IP pretreatment + ICV treatment. VEH= Vehicle (aCSF), SAL=saline vehicle, CMC= carboxymethylcellulose vehicle. Values represent mean ± SEM, n.s. = not significant.