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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Nat Chem Biol. 2015 Nov 9;12(1):9–14. doi: 10.1038/nchembio.1950

Table 1.

Antimicrobial susceptibility profile of E. coli JM83 expressing the BPU-1 β-lactamase

Antimicrobial MIC (µg/ml)
BPU-1 Control1 Fold change
Ampicillin 1,024 2 512
Ampicillin-Clavulanic acid2 32 2 323
Ampicillin-Sulbactam2 1,024 2 03
Ampicillin-Tazobactam2 1,024 2 03
Piperacillin 256 2 128
Ticarcillin 8,192 4 2048
Carbenicillin 8,192 4 2048
Oxacillin 8,192 256 32
Cephalothin 8 4 2
Cephalexin 8 4 2
Cefotaxime 0.125 0.031 4
Ceftriaxone 0.125 0.031 4
Ceftazidime 32 0.25 128
Cefoxitin 8 4 2
Cefepime 4 0.03 128
Aztreonam 8 0.06 128
Imipenem 0.25 0.125 2
Meropenem 0.030 0.015 2
Doripenem 0.045 0.030 1.5
1

Control strain E. coli JM83 with the pHF016 vector.

2

Clavulanic acid, sulbactam and tazobactam were used at a constant concentration of 4 µg/mL.

3

Fold change in comparison to the MIC value for ampicillin.