Table 3.

Factors affecting overall survival in patients with CCA

	Univariate		Multivariate Model 1 (CTC ≥2)		Multivariate Model 2 (CTC ≥5)
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
CTC ≥2	3.1 (1.5–6.1)	<0.01	2.5 (1.1–5.4)	0.02
CTC ≥5	5.4 (1.9–13.0)	<0.01			4.1 (1.4–10.8)	0.01
Age (10 year)	1.3 (1.0–1.6)	<0.01	1.4 (1.1–1.7)	<0.01	1.4 (1.1–1.7)	<0.01
AJCC/UICC T staging	1.4 (1.0–1.9)	0.07
Lymph node invasion	2.9 (1.5–5.6)	<0.01	-	-
Distant Metastasis	6.0 (2.9–12.6)	<0.01	6.4 (2.8–14.5)	<0.01	7.4 (3.2–16.8)	<0.01
Bilobar disease	2.4 (1.3–4.6)	<0.01
Largest tumor size	1.1 (1.0–1.1)	0.14
Multinodular tumor	2.1 (1.1–3.8)	0.02
CA19-9 >100 U/mL	3.7 (1.8–8.2)	<0.01	2.8 (1.3–6.4)	<0.01	2.7 (1.2–6.1)	0.01
Sex (male)	2.1 (1.1–4.5)	0.02
Race (White)	0.4 (0.2–1.4)	0.13
Tumor type		0.45		0.84		0.99
iCCA (ref)	-		-
pCCA/dCCA	0.8 (0.4–1.3)		1.1 (0.6–2.1)		1.0 (0.5–1.9)
PSC	0.6 (0.2–1.4)	0.25
Cirrhosis	0.7 (0.2–1.8)	0.52

Model 1 includes CTC ≥2, Model 2 includes CTC ≥5 as a predictor of overall survival

iCCA: intrahepatic cholangiocarcinoma; pCCA: perihilar cholangiocarcinoma; dCCA: distal cholangiocarcinoma AJCC/UICC; American Joint Committee on Cancer/Union for International Cancer Control