Appendix 1.

STROBE Checklist

	Description	Page location
Title and abstract	Indicate study design and give balanced summary of findings	Pages 1–2
Rationale	Explain the rationale for the study	Pages 3–4
Objectives	State study objective(s)	Page 4
Study design	Present key elements of study design	Page 6
Setting	Describe setting, locations, dates	Page 6
Participants	Describe selection criteria and any matching criteria	Page 6
Variables	Define outcomes, exposures, covariates	Page 7
Data sources	Give how each variable was measured	Page 7
Bias	Describe how sources of bias were managed	Pages 7–8
Quantitative variables	How were quantitative variables handled and were categories used	Page 8
Statistical methods	Describe methods of analysis, missing data, sensitivity analyses	Page 8
Participants	Describe numbers of subjects and any reasons for non-participation	Page 9
Descriptive data	Describe study participants and exposures	Page 9
Outcome data	Report number of events or other outcomes	Page 10
Main results	Give unadjusted and adjusted estimates	Page 10
Other analyses	Report sensitivity analyses	Page 10
Key results discussion	Summarize key findings	Page 11
Limitations	Discuss limitations	Pages 12–13
Interpretation	Give a cautious overall interpretation	Pages 11–13
Generalizability	Discuss external validity	Page 13
Funding	Describe sources of funding and potential conflicts	Page 1

Adapted from reference ¹⁷