Figure 1.

AB attenuates PQ-induced neurotoxicity. NG108-15 cells were treated with various doses of PQ, AB, or AB + PQ for 72 hours. (a) Growth curve of NG108-15 cells with increasing doses of PQ. IC₅₀ of PQ calculated at approximately 50 μM. N = 6. (b) Growth curve of NG108-15 cells with increasing doses of AB. 1 : 10 AB demonstrated significant toxicity and thus was not used in further studies. N = 6. (c) Left panel, growth curve of NG108-15 cells with 50 μM of PQ along with various doses of AB. AB was added at 0 hours, while PQ was added at 24 hours after plating. N = 6. Right panel, analysis of apoptotic NG108-15 cells with 50 μM of PQ along with various doses of AB. Apoptotic fraction was defined as annexin V positive and propidium iodide (PI) negative. N = 4. ^∗ p < 0.05 versus No PQ or AB; ^Ψ p < 0.05 versus PQ-No AB.