Figure 3.

Spatial classifications of pluripotency factors. Upon exit of pluripotency core pluripotency factors get committed to distinct lineages and arising tissues, thus playing a crucial role in directing early lineage decisions in mouse. This image illustrates their spatial classification in the early embryo: neuroectoderm is mainly promoted by Gbx2 and Sox2 and mesendoderm especially by Esrrb, Nanog, Oct3/4, and Tbx3. Further, the extraembryonic tissue is induced by Cdx2, Rex1, Esrrb, Sall4, Oct3/4, and Tbx3. Cdx2: caudal type homeobox  2, Esrrb: estrogen-related receptor β, Gbx2: gastrulation brain homeobox  2, Tbx3: T-box transcription factor 3, Oct3/4: octamer binding transcription factor 3/4, Rex1: Zfp42, Sall4: Sal-like 4, and Sox2: SRY- (sex determining region Y-) box  2.