Figure 1.

Summary of results of human studies on the role of galectin-3 in impaired glucose regulation and insulin sensitivity. Solid geometric figures indicate levels of each target, whereas dotted black lines indicate positive or negative correlation with galectin-3 levels. In the general population, galectin-3 levels are positively correlated with HOMA-IR, a measure of insulin resistance. Conversely, within the diabetic population galectin-3 levels are negatively correlated to HOMA-IR and HbA_1c levels and positively with GDR and ISI. HOMA-IR = homeostasis model assessment of insulin resistance; GDR = glucose disposal rate; ISI = insulin sensitivity index; HbA_1c = hemoglobin A_1c.