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. 2015 Dec 18;2:1. doi: 10.1186/s40482-015-0004-x

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© Carlier et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — In silico and in vivo results of the effects of MSC transplantation on atrophic non-union formation. Ai In silico results for the treatment with the cell transplant injected in the center of the callus. Aii A comparison of experimentally measured (Exp) and numerically calculated (Sim) tissue constituents present within the interfragmentary gap of control (carrier solution injected) and treatment (MSC transplant) groups (^o*p < 0.005, students t test). Simulation results are shown for a central injection of the carrier solution. Bi In silico results for the treatment with the cell transplant injected excentrally in the callus. Bii A comparison of experimentally measured (Exp) and numerically calculated (Sim) tissue constituents present within the interfragmentary gap of control (carrier solution injected) and treatment (MSC transplant) groups (^o*p < 0.005, students t-test). Simulation results are shown for an excentral injection of the carrier solution. C Simulation results for the treatment with the cell transplant injected outside the callus. PFW post fracture week. (adapted from Geris et al. [48], licensed under CC BY 4.0)