Table I.

In vitro activity of SAR245408 against representative panel of PPTP cell lines.

Cell Line	Histotype	Relative IC50 (µM)	R2	Panel R_IC50/ Line R_IC50
RD	RMS	5.3	0.959	2.05
Rh41	RMS	5.3	0.948	2.06
Rh18	RMS	5.8	0.966	1.88
Rh30	RMS	11.3	0.964	0.97
BT-12	Rhabdoid	16.1	0.954	0.68
SJ-GBM2	GBM	18.9	0.975	0.58
CHLA-266	Rhabdoid	7.7	0.983	1.41
CHLA-9	Ewing	6.8	0.850	1.60
CHLA-10	Ewing	2.7	0.959	4.04
CHLA-258	Ewing	10.2	0.947	1.07
TC-71	Ewing	24.5	0.950	0.45
NB-1643	NB	20.3	0.965	0.54
NB-EBc1	NB	23.9	0.953	0.46
CHLA-90	NB	8.5	0.978	1.28
CHLA-136	NB	18.7	0.948	0.58
NALM-6	ALL	7.6	0.990	1.44
COG-LL-317	ALL	13.2	0.930	0.83
RS4;11	ALL	3.8	0.974	2.87
MOLT-4	ALL	10.6	0.957	1.03
CCRF-CEM GM	ALL	14.5	0.966	0.76
CCRF-CEM SY	ALL	14.3	0.959	0.77
Kasumi-1	AML	3.8	0.977	2.91
Karpas-299	NHL	13.1	0.946	0.84
Ramos-RA1	NHL	21.5	0.970	0.51
Median		10.9	0.96	1.00
Minimum		2.7	0.85	0.45
Maximum		24.5	0.99	4.04