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. Author manuscript; available in PMC: 2016 Nov 18.
Published in final edited form as: Neuron. 2015 Nov 18;88(4):667–677. doi: 10.1016/j.neuron.2015.10.038

Figure 3. HD-RAN Proteins in Human Frontal Cortex and Cerebellum and HD Mice.

Figure 3

(A and B) IHC staining of control and HD gray and white matter of (A) frontal cortex and (B) cerebellum using α-RAN and α-Gln (1C2) antibodies show punctate nuclear and cytoplasmic staining with α-polyAla, α-polySer, α-polyLeu, and α-polyCys. GCL, granule cell layer; PCL, Purkinje-cell layer; ML, molecular layer. Staining of the cortex and cerebellum in adult-onset HD cases is variable. IHC images and quantification of percent positive cells represent typical positive regions.

(C) IHC staining of indicated brain regions in N171-82Q and control mice using the α-polyAla, α-polySer. Red, positive staining; blue, nuclear counterstain. See also Figures S3A–S3E.