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. Author manuscript; available in PMC: 2016 Nov 18.
Published in final edited form as: Neuron. 2015 Nov 18;88(4):667–677. doi: 10.1016/j.neuron.2015.10.038

Figure 5. Increased RAN Protein Staining in Juvenile HD.

Figure 5

(A) Schematic diagram summarizing features of adult-onset and juvenile HD pathology.

(B) H&E staining in control, adult-onset, and juvenile-onset HD cases with cerebellar atrophy.

(C) α-polyGln, α-polySer, α-polyCys and α-IBA1staining in cerebellar layers.

(D) Quantitation of IHC-positive cells with 1C2 (polyGln) and α-polySer-Ct, α-polyCys-Ct, and α-IBA1 antibodies. WM, white matter; GCL, granule cell layer; PCL, Purkinje-cell layer; ML, molecular layer. Red, positive staining; blue, nuclear counterstain. Staining of cerebellum in adult-onset HD cases is variable. IHC images and quantification of percent positive cells represent typical positive regions. See also Figures S5A and S5B.