Table 4.

Univariate and multivariate analyses of parameters predicting Gleason score upgrading to clinically significant disease by targeted biopsy over 12-core biopsy

	OR (95% CI)	p Value
Univariate:
PSA cutoff/increment	3.3 (2.2–5.2)	<0.0001
MRI anterior lesions (yes/no)	3.3 (1.9–5.8)	<0.0001
MRI suspicion score/suspicion increase	1.9 (1.1–3.3)	0.02
Prior neg biopsies (yes/no)	1.9 (1.0–3.5)	0.04
No. total biopsy cores/core	1.1 (1.0–1.2)	0.02
Age/10 yrs*	1.4 (0.98–1.9)	0.06
MRI prostate vol/10 ml*	1.1 (0.85–1.0)	0.3
Multivariate:
PSA cutoff/increment	3.4 (2.1–6.0)	<0.0001
MRI anterior lesions (yes/no)	2.6 (1.4–5.1)	0.003
MRI suspicion score/suspicion increase	1.1 (0.61–2.1)	0.7
Prior neg biopsies (yes/no)	1.5 (0.62–2.5)	0.3
No. total biopsy cores/core	1.1 (0.93–1.2)	0.4

^*Not predictors on multivariate analysis.