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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Cancer Res. 2015 Aug 19;13(12):1554–1566. doi: 10.1158/1541-7786.MCR-15-0240

Fig. 7.

Fig. 7

Expression of K1037R mutant EGFR leads to prolonged EGFR phosphorylation and sustained MAPK signaling in human CRC cells. (A) Mutation of K1037 (but not K203) to arginine (R) abolishes acetylated lysine signal in EGFR of HT29 cells. (B) Expression of K1037R mutant EGFR in HCT116 ShNT or ShSrx cells leads to prolonged EGFR tyrosine phosphorylation and sustained MAPK activation. (C) Inhibition of MAPK cascade by a MEK inhibitor (PD98059) abolishes Srx-mediated cell invasion in HT29 cells. (D) Expression of K1037R EGFR mutant (but not the wildtype) rescues the inhibition of cell invasion in HCT116 ShSrx cells.