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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Immunol. 2015 Nov 20;196(1):34–38. doi: 10.4049/jimmunol.1501312

FIGURE 4.

FIGURE 4

FICZ induces IL-22 and resolution of colonic damage in Il1rl2−/− mice. (A) DAI of Il1rl2+/+ (blue) and Il1rl2−/− (red) mice treated for 5 d with DSS followed by normal water for 8 days, in the presence (black line) or absence (no line) of FICZ. (B) H&E staining and (C) histology scoring of colon sections of Il1rl2+/+ and Il1rl2−/− mice treated as in (A). (D) IL-22 mRNA expression in colons from DSS-treated Il1rl2−/− mice in the presence or absence of FICZ (5 d). Data are representative of three independent experiments with five mice per group. *P < 0.05.