Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Cancer Res. 2015 Sep 9;13(12):1533–1543. doi: 10.1158/1541-7786.MCR-15-0237

Figure 3. The combination of mitomycin C and bortezomib induced Bcl-xL phosphorylation and p53 elevation under normoxia and hypoxia.

Figure 3

LS174T (A) and LS180 (B) cells were treated with mitomycin C (2 μg/ml) and/or bortezomib (10 nM) under normoxia and hypoxia for 24 h and p-JNK/JNK, p-p38/p38, p-Bcl-xL/Bcl-xL, and p-p53(Ser46)/p53 were detected with immunoblotting. Actin was used to confirm equal amounts of proteins loaded in each lane.