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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Cancer Res. 2015 Aug 13;13(12):1591–1601. doi: 10.1158/1541-7786.MCR-14-0626

Figure 1. ABC294640 decreases LNCaP cell growth in a dose-dependent manner.

Figure 1

A, Chemical structure of ABC294640 (3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide), hydrochloride salt. B, LNCaP cells were treated with the indicated concentration of ABC294640 for 72 hours and cell survival was quantified by the SRB assay. C, LNCaP cells were cultured in hormone-proficient media and treated with 10 μM (●), 20 μM (▲) ABC294640 or vehicle (■) for 96 hours. Cell growth was determined by trypan blue exclusion cell counting. D, LNCaP cells cultured as in C were treated with 20 μM ABC294640 for 72 hours and analyzed for BrdU incorporation. * p < 0.05 and **p < 0.01 relative to vehicle; #p < 0.01 relative to 10 μM.