Table 2.
Mean, standard deviation, maximum and minimum values for Hb A2 in 242 children according to the presence of α3.7-thalassemia, stratified by type of sickle cell disease.
| α3.7-Thalassemia | n | Average | SD | Minimum–maximum | p-Value |
|---|---|---|---|---|---|
| <0.001a | |||||
| αα/αα | 181 | 3.68 | 0.56 | 1.50–5.20 | 0.001b |
| Hb SS | 104 | 3.57 | 0.61 | 1.50–5.20 | |
| Hb SC | 77 | 3.84 | 0.42 | 2.90–4.80 | |
| −α/αα | 51 | 4.12 | 0.57 | 2.30–4.90 | 0.074b |
| Hb SS | 28 | 3.98 | 0.64 | 2.30–4.90 | |
| Hb SC | 23 | 4.29 | 0.41 | 3.30–4.90 | |
| −α/−α | 10 | 4.86 | 0.23 | 4.50–5.20 | 0.267b |
| Hb SS | 3 | 4.73 | 0.25 | 4.50–5.00 | |
| Hb SC | 7 | 4.91 | 0.22 | 4.60–5.20 | |
| Total | 242 | 3.82 | 0.62 | 1.50–5.20 | <0.001c |
| Hb SS | 135 | 3.68 | 0.65 | 1.50–5.20 | |
| Hb SC | 107 | 4.01 | 0.51 | 2.90–5.20 | |
SD: standard deviation; Hb SS: sickle cell anemia; Hb SC: SC hemoglobinopathy.
Comparison of average Hb A2 values according to presence of α3.7-thalassemia (wild-type, heterozygous and homozygous) independently of type of hemoglobinopathy – non-parametric Kruskal–Wallis test.
Comparison of average Hb A2 values between the types of hemoglobinopathy (Hb SS or Hb SC) for each alpha thalassemia classification (wild-type, heterozygous and homozygous) – non-parametric Mann–Whitney test.
Comparison of average Hb A2 values between the types of hemoglobinopathy (Hb SS or Hb SC) independently of alpha thalassemia classification (wild-type, heterozygous and homozygous) – non-parametric Mann–Whitney test.