Table 2.
Outcomes of studies on the relationship between 5-HTTLPR and depression in adolescents.
| Reference | Sample size | Main outcomes or conclusion | |
|---|---|---|---|
| Stavrakakis et al. (2013) | 1196 | Adolescents’ depressive symptoms are not modified by 5-HTTLPR | |
| Nobile et al. (2009) | 607 | Short alleles were associated with higher affective problems scores | |
| Kohen et al. (2013) | 192 | The s/l vs. l/l genotype showed greater reduction in depression symptoms | |
| Comasco et al. (2013) | 1393 | 5-HTTLPR interacted with unfavorable environment in relation to depressive symptoms | |
| Cutuli et al. (2013) | 267 | Positive G × E effects on depression were found | |
| Priess-Groben and Hyde (2013) | 309 | Short allele confers susceptibility to stress for females with depression | |
| Jenness et al. (2011) | 200 | 5-HTTLPR predict depressive symptoms | |
| Otten and Engels (2013) | 310 | Cannabis use increases the risk of depression only in the presence of 5-HTTLPR short allele genotype | |
| Uddin et al. (2011) | 2574 | The sl genotype carriers had less higher depressive symptom score | |
| Goodyer et al. (2010) | 401 | 5-HTTLPR short allele modify the risk of a new depressive episode associated with elevated morning salivary cortisol | |
| Benjet et al. (2010) | 78 | Short alleles confers vulnerability to depressive symptoms in girls | |
| Goodyer et al. (2009) | 403 | Episode of depression was increased in those with the “s” allele | |
| Laucht et al. (2009) | 309 | LL genotype of 5-HTTLPR displayed significantly higher rates of depressive disorders and more depressive symptoms | |
| Sjöberg et al. (2006) | 200 | Females carrying the short 5-HTTLPR allele tend to develop depressive symptoms | |
| Nederhof et al. (2010) | 1096 | Interaction between 5-HTTLPR polymorphism and childhood adversities did not predict depression score | |
| Cicchetti and Rogosch (2014) | 1096 | G × E interaction of 5-HTTLPR and maltreatment on depression symptoms | |
| Little et al. (2014) | 174 | Structural abnormalities in the left hippocampus may be partly responsible for an indirect association between 5-HTTLPR genotype and depressive illness | |
| Banducci et al. (2014) | 222 | Among girls, but not boys, each copy of the s allele of the 5-HTTLPR was related to increased depressive symptoms | |
| Buchmann et al. (2013) | 259 | The carriers of the BDNF Met and 5-HTTLPR s allele are susceptible to depressive symptoms | |
| Oppenheimer et al. (2013) | 241 | Youth with SS genotype of 5-HTTLPR experienced greatest increases in depressive symptoms when exposed to elevations in materal symptoms | |
| Petersen et al. (2012) | 436 | Stress affect adolescents’ likelihood of experiencing depressed symptoms when they have a low serotonin TE (A/Gmodified5-HTTLPR) genotype | |
| Mata et al. (2010) | 50 | Girls with homozygous for short 5-HTTLPR allele showed stronger association between depressive and bulimic symptoms the long allele | |
| Hankin et al. (2011) | 220 | 5-HTTLPR confers susceptibility to depression via stress reactivity | |
| Uddin et al. (2010) | 524 | 5-HTTLPR sl genotype is a risk of depressive symptom in adolescent male | |
| Aslund et al. (2009) | 1482 | A GxE interaction effect of 5HTTLPR ss allele was found among girls, not boys | |
| Eley et al. (2004) | 377 | A significant genotype-environmental risk interaction for 5HTTLPR in the risk of depression in girls only |