Table 3.
Outcomes of studies on the relationship between BDNF and dopaminergic pathway and depression in adolescents.
| Reference | Sample size | Main outcomes or conclusion |
|---|---|---|
| Stavrakakis et al. (2013) | 1196 | Adolescents’ depressive symptoms are not modified by BDNF |
| Comasco et al. (2013) | 1393 | Depressive symptoms and depression were more common among carriers of either the Val/Val or Met genotypes |
| Goodyer et al. (2010) | 401 | BDNF (Val66Met) modify the risk of a new depressive episode associated with elevated morning salivary cortisol |
| Chen et al. (2012) | 780 | Interaction between BDNF Val66Met polymorphism and environmental stress on depression was observed |
| Nederhof et al. (2010) | 1096 | Depression score was not significantly predicted by interaction between BDNF Val66Met polymorphism and childhood adversities |
| Mata et al. (2010) | 82 | BDNF met allele moderate the relation between exercise and depressive symptoms |
| Duncan et al. (2009) | 217 | Val/Val genotype correlated with higher levels of depression symptoms |
| Hilt et al. (2007) | 100 | Val/Val genotype was associated with more depressive symptoms |
| Cicchetti and Rogosch (2014) | 1096 | G × G × E interaction of BDNF, 5-HTTLPR/CRHR1 and maltreatment on depression symptoms |
| Cruz-Fuentes et al. (2014) | 246 | Possession of BDNF Met allele was statistically linked with a resilient phenotype of major depression disorder |
| Buchmann et al. (2013) | 259 | The carriers of the BDNF Met and 5-HTTLPR s allele are susceptible to depressive symptoms |
| Chen et al. (2013) | 780 | BDNF Val allele modulates the influence of environmental stress on depression |
| Stavrakakis et al. (2013) | 1196 | Adolescents’ depressive symptoms are not modified by COMT |
| Guo and Tillman (2009) | 2286 | DRD2*304/178 and DRD4*379/379 genotype are associated with a level of depressive symptoms |
| Bobadilla et al. (2013) | 1882 | DRD4 polymorphism is linked to comorbid marijuana use and depression |