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. 2015 Dec 7;2015:457193. doi: 10.1155/2015/457193

Figure 3.

Figure 3

Expression of PTEN/p-PTEN, AKT/p-AKT, Bad, Caspase-3/Caspase-3 cleaved in control, and Bufalin-treated cells. The expression of PTEN was upregulated in cells treated with 3 μM Bufalin, while the p-PTEN were significantly decreased in cells treated with 0.3 μM and 3 μM Bufalin compared to the control group (P < 0.05). There was significant downregulation of p-AKT in cells treated with 0.3 μM and 3 μM Bufalin (P < 0.05). The Bad expression was increased (P < 0.05) in Bufalin-treated cells. The treatment of 0.3 μM and 3 μM Bufalin caused cleaves of Caspase-3 (fragments with molecular weight of 17 or 19 kd).