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. 2015 Dec 21;6:378. doi: 10.3389/fphys.2015.00378

Figure 4.

Figure 4

Expression of neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) in the vagal sensory ganglia and brainstem. Representative photomicrographs showing differential expression of CGRP in the (A) nodose ganglia, (A′) jugular ganglia, (B) nucleus of the solitary tract (nTS), and (B′) paratrigeminal nucleus (Pa5). Bar charts show quantitative analysis of CGRP and SP expression in (A″) vagal ganglia and (B″) brainstem. Neuropeptide expression is more abundant in the jugular than the nodose ganglia. SP expression in the brainstem is similar in the nTS and Pa5, whereas expression of CGRP is significantly higher in the Pa5 compared to the nTS. Data represent the mean ± SEM number neurons (A″) or intensity of immunostaining (B″) quantified from a minimum of 10 tissue sections of vagal ganglia obtained from n = 6 separate experiments. *P ≤ 0.05 and **P ≤ 0.01 significantly different pairwise comparison. Additional abbreviations: dmnX, dorsal motor nucleus of the vagus nerve; sp5, spinal trigeminal tract.