Figure 4.

Effect of manuka honey on the gastric mucosal histopathological changes detected by H&E staining in ethanol-induced gastric ulceration model. (a) Control: intact mucosal layers; (b and c) ethanol (ulcer): ulcer with marked maceration of gastric mucosa; necrosis and hemorrhage (arrows). In some animals there is coagulative necrosis of superficial layers (white arrows) and evidence of submucosal widening indicating edema (stars); (d) omeprazole: normal gastric glands with focal loss of superficial mucous cells and hemorrhagic spots; (e) manuka honey: apparently normal mucosa (sections are H&E stained ×20).