Table 4.
A summary of select reported Ki-67 labeling indices in lung carcinoid tumors.
| Studies | Number of cases | % of Ki-67 positive cells, mean (range) | Counting method | |
|---|---|---|---|---|
| TC | AC | |||
| Costes et al. 1995 [12] | 47 | 0.45 (0–3.04) | 2.43 (0–6.05) | CIAM |
| Arbiser et al. 2001 [14] | 10 | 1 | 9 | MCM |
| Igarashi et al. 2004 [16] | 18 | 1.3 (0.3–2.3) | 8.6 (0.2–17) | MCM |
| Pelosi et al. 2005 [15] | 7 | 0.5 (0-1) | 7.2 (1–17) | NS |
| Walts et al. 2012 [19] | 101 | 3.7 | 18.8 | CIAM |
| Zahel et al. 2012 [21] | 200 | 1.8 | 3.7 | MCM |
| Rindi et al. 2014 [20] | 197 | <4 | 4–<25 | MCM, AACAM, and CAMM |
| Present case | 48 | 0.72 | 0.95 | MCM and CIAM |
CIAM indicates computer image analysis method; MCM: manual conventional method; NS: not specified; AACAM: Aperio automated computer assisted method; CAMM: computer assisted manual method; TC: typical carcinoid; AC: atypical carcinoid.