Table 3.

Pharmacogenetics of other perioperative medications.

Drug	Description	Gene(s) affected by polymorphism	Genetic variant	Phenotypic effect of polymorphism
Fentanyl	μ-opioid receptor agonist inhibiting neurotransmission	OPRM1	304 A/G	Variations in median effective dose required to achieve analgesic effect [38]
Suxamethonium	Depolarising neuromuscular blocker	BChE	293A > G	Reduced hydrolysis, increased duration of action leading to prolonged neuromuscular blockade and apnoea [39]
1699G > A
695T > A
RYR1	Multiple at 19q13.1	Malignant hyperthermia [40]
CACNA1S	c520C > T	Malignant hyperthermia [41]
Rocuronium	Non-depolarising neuromuscular blocker	SLCO1B1	rs2306283 A > G	Reduced elimination, increased duration of action and recovery time [42]
ABCB1	rs1128503 C > T
Ondansetron	Anti-emetic 5-HT3 receptor antagonist	ABCB1	2677 TT	Increased bioavailability, reduction in PONV [43]
3435 TT