Table 1. Experimental runs for FEs. In pattern, + and − means high and low levels, respectively. 0 indicates a center point.

Run	pattern	Col I (mg/mL)	LN (mg/mL)	FN (mg/mL)
1	−−−	0.00	0.00	0.00
2	+−−	0.83	0.00	0.00
3	−+−	0.00	0.83	0.00
4	−−+	0.00	0.00	0.83
5	−++	0.00	0.83	0.83
6	++−	0.83	0.83	0.00
7	+−+	0.83	0.00	0.83
8	+++	0.83	0.83	0.83
9	000	0.42	0.42	0.42