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. 2015 Dec 21;5:18709. doi: 10.1038/srep18709

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Copyright © 2015, Macmillan Publishers Limited

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(A) Effect of UNC0638 on the tumor growth of PANC-1-R cells in the orthotopical animals. The picture showed the tumors harvested from the sacrificed amimals and tumor volume was calculated using the equation: tumor volume = (length × width²)/2. (B) Immunohistochemical analysis to show the expression of G9a, E-cadherin, PCL3 and KDM7A of tumor tissues obtained from mice received vehicle (DMSO) or UNC0638 treatment. (C) Correlations between G9a and PCL3 or KDM7A of 78 human pancreatic tumor tissues were analyzed by using the GSE15471 dataset from Oncomine. Correlation coefficient and p-value were shown. (D) A cartoon illustrates of the proposed models by which G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation.